This Is Us was a hit show on NBC that was known for its heartbreaking plots, but one moment in particular easily outranks any other scene as the saddest. In its six season run, the show seemingly explored every possible trauma one family could go through, with This Is Us' cast and characters beautifully and tactfully handling such scenes as the Pearsons worked to persevere. One death, however, was one of the biggest horrors that affected the entire family rather than individual members at a time, which continued to influence many of the Pearson family's most tragic storylines.