Director of The Substance, Coralie Fargeat, has revealed that a continuation of the smash-hit horror film is not in the cards. Released in 2024, the psychological body horror film revolved around a fading film star who, on the heels of being fired from her aerobics TV show, discovers the titular black market drug, which allows her to transform into a younger version of herself. The Substance quickly became a critical and commercial standout of the year, landing five Golden Globe nominations, including Best Motion Picture – Comedy or Musical.

https://screenrant.com/the-substance-chances-2-coralie-fargeat-response/