The biggest challenge that Avengers: Secret Wars faces has been made close to impossible by the animated Spider-Verse movies. While Tom Holland's Peter Parker protects the Marvel Cinematic Universe as its friendly neighborhood Spider-Man, the animated Spider-Verse trilogy stars Shameik Moore's Miles Morales as its main Spider-Man. Both the Spider-Verse films and the MCU have in common one very important element: the multiverse. Miles' adventures, as the name of the franchise reveals, are all about the character interacting with Spider-Man variants and traveling to different universes.
https://screenrant.com/spider-verse-avengers-6-secret-wars-multiverse-crossover-impossible/