The end of Spider-Man: No Way Home set up a very interesting direction for Spider-Man 4. With most of the MCU now forgetting about Peter Parker, it seems like he will be on his own for the first time in the franchise. Even though there have already been three standalone Spider-Man movies in the MCU timeline, this seems like the first time Peter is tasked with standing alone without another heavy-hitter from the Avengers having his back. This seems even more likely given the speculation that he will be going up against Kingpin as the film's villain.
https://screenrant.com/spider-man-4-villain-theory-break-mcu-trend/