The most recent Resident Evil 4 Remake trailer spoils a massive change in the original game’s story. The Resident Evil Remakes have a habit of changing minor elements of the classic Resident Evil plots while leaving the overall effect of the games intact. Resident Evil 2 Remake, for example, has Leon and Claire meet at a gas station on the Raccoon City limits in a brief, new playable section of the story, instead of meeting at the site of the outbreak. RE4 Remake looks set to make many similar small changes.
https://screenrant.com/re4-remake-trailer-luis-death-story-change-krauser/