For a long time, Jojo's Bizarre Adventure had a reputation for being ultra-masculine, and while it still does to some extent, that reputation definitely began to change once Jolyne Cujoh, the series' first female JoJo, appeared. As it turns out, though, series creator Hirohiko Araki actually had a very difficult time getting to the point where he was even allowed to make his protagonist a girl.
https://screenrant.com/jojos-bizarre-adventure-jjba-araki-fight-first-female/