There are several movies based on the I Am Legend novel by Richard Matheson, and the sequel to the version starring Will Smith could incorporate the best aspects of each. Like the 2007 film, the book I Am Legend tells the story of a man named Robert Neville who believed he was the last person on Earth who hadn't been infected with a deadly virus. From here, the stories begin to differ drastically. The same is true for other screen adaptations, which each explore unique themes and show a different conclusion to the protagonist's story. Ultimately, this leaves a lot of inspiration for I Am Legend 2.
https://screenrant.com/i-am-legend-2-movie-adaptation-sequel-influence/