House was a landmark medical procedural drama, and though it was more about the medicine and the characters than the antagonists, the biggest villains of the TV show made an impact. The series stars Hugh Laurie as the titular character, Dr. Greg House. He has many misadventures, diagnosing patients as a misanthropic but brilliant diagnostician. Alongside him are a revolving cast of young doctors he’s teaching, his best friend, James Wilson (Robert Sean Leonard), and Lisa Cuddy (Lisa Edelstein). Above all, House is a character study that delves into the mind of a troubled and genius man.
https://screenrant.com/house-biggest-villains-ranked-worst-best/