Grey’s Anatomy is a comedy as well as a drama, and has established some now-iconic running jokes over the years. Lead by sarcastic and brilliant personalities such as Dr. Meredith Grey (Ellen Pompeo) and Dr. Cristina Yang (Sandra Oh), as well as some hilariously positive characters like Dr. Derek “McDreamy” Shepherd (Patrick Dempsey) and Dr. Arizona Robbins (Jessica Capshaw), there are plenty of jokes to go around on Grey’s Anatomy. These beats break up or carefully blend with the show’s more dramatic elements.