On a trip to visit his mother in Israel last year, Lyor Cohen, YouTube’s global head of music, asked her one of those big life questions that’s impossible to answer with anything but a big answer.

“She has 16 grandchildren and four sons, she’s 92 years old, and she is moving around this world by herself and still enjoying her grandchildren, healthy,” said Cohen. “And I said to her, ‘You’re a very, very lucky person.’ And she said, ‘Yes, I know that.’ And I said, ‘So, why are you so lucky?’

Without hesitation, she replied, “The more you give, the more you receive.”

At 63, with three kids and an illustrious career in music, Cohen said it’s this giving spirit that inspired him to accept this year’s Spirit of Life award from City of Hope, one of the country’s leading cancer treatment and research centers.

“We’re in the giving business and so we’re grateful to be here and to have the privilege,” said Cohen. “It’s a privilege to do it, but you have to get out of your normal grind to recognize that.”

The honor, bestowed by City of Hope’s music, film and entertainment industry (MFEI) fundraising group, is reserved for entertainment industry titans and has helped the MFEI group raise $150 million since launching in 1973. Now in its 50th year, recent recipients in music include Republic Records founders/chief executives Monte and Avery Lipman (2022), Epic Records chairperson/CEO Sylvia Rhone (2019) and Sony Music Publishing chairman/CEO Jon Platt (2018). As such, the events around them are regularly a who’s-who of industry heavyweights and well-wishers leading up to the gala dinner where the award is presented, which this year will take place Oct. 18 at the Pacific Design Center in Los Angeles.

In April, before the monthslong rollout of events including the All In For Hope Poker Tournament in May and the Music Trivia Bowl in July began, Cohen and seven of his staff members woke up early to drive over 100 miles from the Coachella Valley in rush hour traffic for a tour of the City of Hope campus in Duarte, Calif., just outside Los Angeles. It was the morning after the Coachella Valley Music and Arts Festival’s first weekend, where Cohen’s team oversaw what was likely the largest festival livestream event ever, broadcasting to more than 45 million people worldwide, according to the company. Many of them noted they hadn’t even had a cup of coffee yet.

Cohen, the tallest of the bunch, dressed in all black with a scarf around his neck, led the group, which also included Universal Music Publishing Group, North America president Evan Lamberg, entertainment lawyer Dina LaPolt, Culture Collective founder/CEO Jonathan Azu and Spirit Music Group chairman David Renzer — all of whom are on the City of Hope MFEI Board — as they followed City of Hope staff around the expansive 100-plus acre grounds.

There, they spoke with doctors and scientists to better understand the organization’s research efforts and care services. One of the key advantages City of Hope has in the field, several staff members explained, is that the proximity of scientists, treatment staff and manufacturing facilities, all of which are on-site, allows cross-collaboration that brings their research — seeking cures for cancer, HIV/AIDS and other life-threatening diseases — directly to patients without delay. Throughout, Cohen listened closely and expressed an intent to focus on how to address health disparities for Black people in the United States to create more equitable access to healthcare and establish greater trust in the system.

“I’ve made a living on Black music,” he said, “and what I’m particularly interested in is figuring out how the Black community could demystify getting early treatment and understanding about cancer and how they get the opportunity to help educate and eradicate cancer in these communities.”

Cohen launched his career in the 1980s New York hip-hop scene as a road manager for Russell Simmons‘ Rush Productions before going on to manage the label. He later headed up Def Jam and then Warner Music Group before co-launching 300 Entertainment and, in 2016, joining YouTube. He had a hand in the careers of Public Enemy, DJ Jazzy Jeff & the Fresh Prince, De La Soul, Eric B. & Rakim, A Tribe Called Quest, Jay-Z, DMX, Ja Rule and Ludacris. He acknowledges this is an opportunity to support the people and culture that built his success.

Supporting economically disadvantaged and racially diverse communities facing barriers that limit their ability to find and sustain specialized care was the focus of City of Hope’s Closing the Care Gap event on Aug. 29 and has been at the center of the organization’s MFEI fundraising since 2018. According to City of Hope, only 20% of cancer patients in the United States are treated at National Cancer Institute-designated cancer centers, which can sometimes mean the difference between life and death. It’s something the City of Hope treatment and research center is addressing through community partnerships, government policy, expansion and diversifying its own workforce.

“My big takeaway is that there are so many people that have committed a lifetime to helping others that are selfless, that are so enthusiastic about solving some of these big problems,” Cohen said after the tour. “I saw and met many of the doctors here that loved the fact that they were in an organization that’s biased to speed of getting things done, and breaking the code and making things happen. I felt like this is a joyful place to work and a joyful place to solve these problems.”