Warning: contains spoilers for Deadpool #4!In a momentous change to Marvel lore, the Regeneratin’ Degenerate Wade Wilson – aka Deadpool – was just stripped of his ultra-powerful healing factor. Deadpool’s healing makes him essentially immortal, with many of Marvel’s greatest weapons having failed to do any permanent damage to his unique body. Now, all of that is in the past, as Deadpool is not only rendered vulnerable to normal weapons, but finds himself brutalized and targeted for death by the new villain who took his greatest power.
https://screenrant.com/deadpool-lose-healing-factor-muramasa-death-grip/