The confrontation between Boruto and Mitsuki after every ninja's perception of reality had been unconsciously altered by the villain Eida in the manga would have greatly benefited from the additional context that only the earlier anime-only Mitsuki Disappearance Arc can provide. Without the anime, Mitsuki is just uncharacteristically furious with Boruto, who he sees as Kawaki. But there's a reason why Mitsuki reacts so passionately, and it's because both Mitsuki and Kawaki share a similar past and special devotion to Naruto. Unfortunately for manga fans though, this context is completely lost in the manga.
https://screenrant.com/boruto-betrayal-better-mitsuki-dissapearance-arc-manga-canon/