The best Brian and Stewie episodes in Family Guy history remain some of the best for the animated series overall thanks to their strong relationship. While characters like Peter, Quagmire, Meg, and even Lois to an extent, are good for rapid-fire jokes, Brian and Stewie have a deeper connection and often bring the heart to the series that otherwise would just be an afterthought. Through Family Guy’s run, Brian and Stewie seem to have grown even closer throughout the years, and while they weren’t the original partners in crime, they are easily the best duo on the show now.
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