In Jojo’s Bizarre Adventure, the sixth part, Stone Ocean, was hailed for its decision to have a female Stand-user as its main character, in the form of Jolyne Cujoh, a first for the series despite its long run. However, a much earlier installment in the epic that is Jojo’s Bizarre Adventure almost took this title first, but series creator Hirohiko Araki ended up changing his plans at the last minute.
https://screenrant.com/jojo-almost-first-female-hero-years-before-jolyne/