My Lady Jane is a historical fiction based on actual events in Tudor England. While My Lady Janes characters and royal structure are rooted in fact, the show itself takes many creative liberties. My Lady Jane describes itself as a radical retelling of English royal history, in which King Henry VIIIs son Edward does not die of tuberculosis, Lady Jane Grey is not beheaded, and neither is her rascal of a husband Guildford. The actual history or the era is recapped briefly in the introduction to the pilot episode, which then sets up the series’ intrigue, which revolves around the possibility of an alternate history.

https://screenrant.com/my-lady-jane-grey-real-person-true-story-explained/