Tammy Slaton and Amy Slaton of 1000-lb Sisters fame have lost a significant amount of weight over the years, and their faces have changed so much throughout their journey. When the beloved unscripted show premiered in 2020, the Slaton sisters weighed a combined 1000 pounds, which is where the series got its provocative title. During the premiere episode of the entire series, Amy and Tammy stepped on an industrial scale to weigh in for the show. Amy stepped up, and the scale revealed that she weighed over 400 pounds, while Tammy’s scale read that she weighed over 600 pounds.