1000-lb Sisters stars Tammy Slaton and Amy Slaton have gone through incredible weight-loss journeys, leading them to post full-length photos of their slimmed-down bodies on Instagram. When the show first premiered in 2020, Amy and Tammy weighed over 400 pounds and over 700 pounds, respectively. The Slaton sisters have attributed their weight gain to genetics, socioeconomic factors, and emotional eating. Nonetheless, they are inspiring others with their incredible journey.