1000-lb Sisters centers around the weight loss journeys of Amy Slaton and Tammy Slaton, but their sisters, Misty Wentworth and Amanda Halterman, are there every step of the way. The Slaton sisters and their brother, Chris Combs, grew up together in Shawneetown, Illinois, and always stayed close. They were raised by a single mother and never had a lot of money, so they’ve been through some tough times. Over the years, the Slatons have gone through their share of ups and downs, but they’ve always had each other’s backs.