Monk (2002-2009) followed the life of former detective Adrian Monk (Tony Shalhoub), an investigative genius living with obsessive-compulsive disorder and struggling to cope after the brutal murder of his wife, a premise that often resulted in heartbreaking episodes. With the support of his nurse and personal assistant Sharona, Adrian returns to work as a consultant for the San Francisco Police Department. Monk’s primary drive is to find who killed Trudy, and the circumstances he winds up in along the way are comedic and tragic in equal measure.

https://screenrant.com/monk-most-heartbreaking-episodes-list/