While his time playing Guardians of the Galaxy's Drax may be over, it looks as though Dave Bautista would like to play a villain in the MCU's future. Having been given a very satisfying ending as seen in James Gunn's Guardians of the Galaxy Vol. 3, a future appearance from Drax seems unlikely in the MCU. As such, there may well be room for Bautista to take on a new role in the MCU going forward, albeit one that's more sinister.
https://screenrant.com/mcu-villains-dave-bautista-play-after-drax-ending/