There's no shortage of side activities in Marvel's Spider-Man 2, with an abundance of suits for both Peter and Miles often unlocked as a reward for completing them. While some side activities such as "The Flame" can function somewhat independently of the game's main narrative, and act as a way to set up a potential future DLC storyline, others such as the Emily-May Foundation experiments feed directly into Peter Parker and Harry Osborn's main aspirations to "heal the world".
https://screenrant.com/marvels-spiderman-2-missing-emf-experiment/