Mary Jane Watson plays a significant role in Marvel's Spider-Man 2, both from a narrative perspective as Peter's girlfriend, but also as a temporarily playable character, and most interestingly as part of one of the game's more surprising twists. MJ was introduced to the Spider-Man canon in 1965; since then she has gone on to become Peter Parker's main love interest and the principal beneficiary of his affection in the franchise's many movies, comics, and video games.

https://screenrant.com/marvels-spiderman-2-story-mary-jane-mj-scream/