Cuddy left House before the final season aired and didn’t even return for the finale, and while it was shocking for viewers at the time, Lisa Edelstein has been open about why she left the show. Apart from Hugh Laurie’s Dr. Gregory House, the genius Head of Diagnostic Medicine at a hospital in New Jersey, House MD featured a great supporting cast, including Lisa Edelstein’s Dr. Lisa Cuddy. The Dean of Medicine at the hospital and Gregory House’s boss throughout the show, Cuddy acknowledged the genius of her underling, but was regularly exasperated by House’s frequent rule-breaking, lack of stricter, and disregard for even basic manners.
https://screenrant.com/house-show-what-happened-cuddy-finale-absence/